In December 1986, Tom and Nancy Pawel gifted 1,514 acre of land for a research park to the TRTF and UT Health San Antonio established the institute of Biotechnology at the TRTF Research Park. In 1990, TRTF developed Research Plaza I/II which created facilities for growing bio companies. In 1993, BioMedical Enterprises, Inc. [BME] established manufacturing facility at the Research Park, and in 2000, UT Health and Cancer Treatment and Research Center develop labs and new facilities at the Research Park. And in 2015, Microsoft purchased land at the Research Park and established a Data Center.